Active Ingredient
Lactulose 667mg/ml 

Purpose
Laxative
 
Directions:
Constipation: For the treatment of chronic constipation in adults, the usual initial dosage of pms-LACTULOSE is 10 g to 20 g (15 mL to 30 mL) daily. Dosage may be increased to 40 g (60 mL) daily if necessary. Following oral pms-LACTULOSE administration, 24-48 hours may be required to restore normal bowel movements. Portal-systemic Encephalopathy: For the prevention and treatment of PSE in adults, the usual initial oral dosage of pmsLACTULOSE is 20 g to 30 g (30 mL to 45 mL of pms-LACTULOSE) 3 or 4 times daily. Dosage is then adjusted every 1-2 days as necessary to produce 2 or 3 soft stools daily. Some clinicians recommend that dosage be adjusted according to the acidity of the colonic contents by pms-LACTULOSE Prescribing Information Page 11 of 14 measuring stool pH (with indicator paper) at the start of therapy and adjusting the dosage until stool pH is about 5. This pH is usually achieved when the patient has 2 or 3 soft stools daily during pms-LACTULOSE therapy. For most adults, pms-LACTULOSE dosage is usually 60 g to 100 g (90 mL to 150 mL) daily, although some patients may require a higher dosage.